MicroRNAs in kidney injury and disease
N Mahtal, O Lenoir, C Tinel, D Anglicheau… - Nature Reviews …, 2022 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …
Diabetic nephropathy: novel molecular mechanisms and therapeutic targets
C Zoja, C **naris, D Macconi - Frontiers in pharmacology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …
[HTML][HTML] Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal miR-146a-5p which targets IRAK1
X Li, J Liao, X Su, W Li, Z Bi, J Wang, Q Su, H Huang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) that
is associated with high morbidity and mortality, and for which specific treatments are lacking …
is associated with high morbidity and mortality, and for which specific treatments are lacking …
miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity
JA Pan, Y Tang, JY Yu, H Zhang, JF Zhang… - Cell Death & …, 2019 - nature.com
Clinical therapy of doxorubicin (DOX) is limited due to its cardiotoxicity. miR-146a was
proved as a protective factor in many cardiovascular diseases, but its role in chronic DOX …
proved as a protective factor in many cardiovascular diseases, but its role in chronic DOX …
Association of MicroRNA‐146a with type 1 and 2 diabetes and their related complications
M Ghaffari, S Razi, H Zalpoor… - Journal of Diabetes …, 2023 - Wiley Online Library
Most medical investigations have found a reduced blood level of miR‐146a in type 2
diabetes (T2D) patients, suggesting an important role for miR‐146a (microRNA‐146a) in the …
diabetes (T2D) patients, suggesting an important role for miR‐146a (microRNA‐146a) in the …
Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis
Background Urinary exosomes, especially microRNAs (miRNAs) packaged within, are ideal
sources of renal damage markers. We investigated the association between exosomal miR …
sources of renal damage markers. We investigated the association between exosomal miR …
Long noncoding RNA LINC01619 regulates microRNA-27a/forkhead box protein O1 and endoplasmic reticulum stress-mediated podocyte injury in diabetic …
X Bai, J Geng, X Li, J Wan, J Liu, Z Zhou… - Antioxidants & redox …, 2018 - liebertpub.com
Aims: Altered activities of long noncoding RNAs (lncRNAs) have been implicated in the
regulation of microRNAs. microRNA-27a (miR-27a) upregulation has been shown to induce …
regulation of microRNAs. microRNA-27a (miR-27a) upregulation has been shown to induce …
Inhibition of angiotensin-converting enzyme ameliorates renal fibrosis by mitigating DPP-4 level and restoring antifibrotic MicroRNAs
SP Srivastava, JE Goodwin, K Kanasaki, D Koya - Genes, 2020 - mdpi.com
Two class of drugs 1) angiotensin-converting enzyme inhibitors (ACEis) and 2) angiotensin
II receptor blockers (ARBs) are well-known conventional drugs that can retard the …
II receptor blockers (ARBs) are well-known conventional drugs that can retard the …
MicroRNAs associated with the development of kidney diseases in humans and animals
O Ichii, T Horino - Journal of toxicologic pathology, 2018 - jstage.jst.go.jp
Mature microRNAs (miRNAs) are single-stranded RNAs with approximately 18–25 bases,
and their sequences are highly conserved among animals. miRNAs act as …
and their sequences are highly conserved among animals. miRNAs act as …
MicroRNAs and their delivery in diabetic fibrosis
The global prevalence of diabetes mellitus was estimated to be 463 million people in 2019
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …