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Dendritic cells and macrophages in the kidney: a spectrum of good and evil
Renal dendritic cells (DCs) and macrophages represent a constitutive, extensive and
contiguous network of innate immune cells that provide sentinel and immune-intelligence …
contiguous network of innate immune cells that provide sentinel and immune-intelligence …
Membranoproliferative glomerulonephritis
Membranoproliferative glomerulonephritis is an uncommon kidney disorder characterized
by mesangial cell proliferation and structural changes in glomerular capillary walls. It can be …
by mesangial cell proliferation and structural changes in glomerular capillary walls. It can be …
TLR4 links podocytes with the innate immune system to mediate glomerular injury
MC Banas, B Banas, KL Hudkins… - Journal of the …, 2008 - journals.lww.com
Toll-like receptors (TLR) classically recognize pathogen-associated danger signals but are
also activated via endogenous ligands. For evaluation of their role in inflammatory kidney …
also activated via endogenous ligands. For evaluation of their role in inflammatory kidney …
Mechanisms of immune-deposit formation and the mediation of immune renal injury
The passive trap** of preformed immune complexes is responsible for some forms of
glomerulonephritis that are associated with mesangial or subendothelial deposits. The …
glomerulonephritis that are associated with mesangial or subendothelial deposits. The …
Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition
Basophils, recruited from the blood to tissues, have been implicated by their presence in
diverse allergic disorders including bronchial asthma, allergic rhinitis, and cutaneous …
diverse allergic disorders including bronchial asthma, allergic rhinitis, and cutaneous …
The regulation of lymphocyte activation by inhibitory receptors
PJ Leibson - Current opinion in immunology, 2004 - Elsevier
The ability of activating immune recognition receptors on lymphocytes to regulate cellular
activation and function can be profoundly altered by co-stimulation with inhibitory receptors …
activation and function can be profoundly altered by co-stimulation with inhibitory receptors …
Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
JY Chen, CM Wang, CC Ma, SF Luo… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To investigate the possible association of the Fcγ receptor IIb (FcγRIIb) Ile/Thr187
transmembrane domain polymorphism, which significantly affects receptor signaling, with …
transmembrane domain polymorphism, which significantly affects receptor signaling, with …
Macrophages and the kidney
An understanding of the role of macrophages at different time-points in renal inflammation,
and the development of techniques for modulating macrophage activation in vivo, will …
and the development of techniques for modulating macrophage activation in vivo, will …
Pathogenic mechanisms in membranoproliferative glomerulonephritis
Understanding the contribution of complement activation and innate immunity to the
evolution of membranoproliferative glomerulonephritis promises to provide new therapeutic …
evolution of membranoproliferative glomerulonephritis promises to provide new therapeutic …
Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide
Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy
to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with …
to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with …