The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

Members of the solute carrier organic anion transporting polypeptide (OATPs) family
function as transporters for a large variety of amphipathic organic anions including …

A wide range of endogenous and xenobiotic organic ions require facilitated transport
systems to cross the plasma membrane for their disposition. In mammals, organic cation …

Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by
mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the …

In mammals, the kidney plays an essential role in maintaining blood homeostasis through
the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion …

The human organic cation transporter 1 (hOCT1), also known as SLC22A1, is integral to
hepatic uptake of structurally diversified endogenous and exogenous organic cations …

Organic anion transporters (OATs) of the SLC22 family have crucial roles in the transport of
organic anions, including metabolites and therapeutic drugs, and in transporter-mediated …

ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

Our lab previously established that metformin, a first-line type two diabetes treatment,
activates the Nrf2 pathway and improves post-stroke recovery. Metformin's brain …