Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

Genome-wide association studies have identified many loci associated with hair and skin
disease, but identification of causal variants requires deciphering of gene-regulatory …

Several of the thousands of human long non-coding RNAs (lncRNAs) have been
functionally characterized,,,; however, potential roles for lncRNAs in somatic tissue …

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of
regulators of gene expression. lncRNAs exhibit several distinctive features that confer …

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …

Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell
compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and …

A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …

The skin epidermis and its array of appendages undergo ongoing renewal by a process
called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue …

Glucose is a universal bioenergy source; however, its role in controlling protein interactions
is unappreciated, as are its actions during differentiation-associated intracellular glucose …