Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Immunological memory can be defined as a quantitatively and qualitatively enhanced
immune response upon rechallenge. For natural killer (NK) cells, two main types of memory …

Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can
rapidly respond against pathogens and tumors in an antigen-independent manner and then …

The purpose of this perspective is to describe a critical advance in understanding how
immune responses work. Macrophages are required for all animal life:'Inhibit'type …

Natural killer (NK) cells have traditionally been considered nonspecific components of
innate immunity, but recent studies have shown features of antigen-specific memory in …

Adaptive immune responses are defined as antigen sensitization–dependent and antigen-
specific responses leading to establishment of long-lived immunological memory. Although …

The liver is considered a preferential tissue for NK cells residency. In humans, almost 50% of
all intrahepatic lymphocytes are NK cells that are strongly imprinted in a liver-specific …

Type I interferons (IFNs) are known to mediate antitumor effects against several tumor types
and have therefore been commonly used in clinical anticancer treatment. However, how IFN …

Due to their ability to kill cancer cells and produce proinflammatory cytokines, natural killer
(NK) cells have long been of clinical interest for their antitumor properties. The recent …

Natural killer (NK) cells are innate lymphocytes specialized in immune surveillance against
tumors and infections. To reach their optimal functional status, NK cells must undergo a …