Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone
During the last decade major efforts have been made to develop synthetic reagents that bind
sequence specifically (or selectively) to double stranded DNA thereby in principle being …
sequence specifically (or selectively) to double stranded DNA thereby in principle being …
Triple helix formation and the antigene strategy for sequence-specific control of gene expression
D Praseuth, AL Guieysse, C Helene - Biochimica et Biophysica Acta (BBA) …, 1999 - Elsevier
Specific gene expression involves the binding of natural ligands to the DNA base pairs.
Among the compounds rationally designed for artificial regulation of gene expression …
Among the compounds rationally designed for artificial regulation of gene expression …
DNA: structure and function
RR Sinden, CE Pearson, VN Potaman… - Advances in genome …, 1998 - Elsevier
Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …
Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair
G Wang, MM Seidman, PM Glazer - Science, 1996 - science.org
When mammalian cells were treated with triplex-forming oligonucleotides of sufficient
binding affinity, mutations were specifically induced in a simian virus 40 vector contained …
binding affinity, mutations were specifically induced in a simian virus 40 vector contained …
Hydrogen bond versus anti-hydrogen bond: a comparative analysis based on the electron density topology
The theory of atoms in molecules is used to examine the nature of anti-hydrogen bond (anti-
H bond) interaction. Contrary to what is found in normal hydrogen bond (H bond) …
H bond) interaction. Contrary to what is found in normal hydrogen bond (H bond) …
Triplex forming oligonucleotides: sequence-specific tools for gene targeting
Sequence-specificity is the key to effective genetic targeting. With specificity, targeted genes
can be manipulated in multiple ways; without it, gene therapy agents become loose canons …
can be manipulated in multiple ways; without it, gene therapy agents become loose canons …
Oligonucleotide N3'→ P5'phosphoramidates
SM Gryaznov, RG Schultz, J Chen - US Patent 5,965,720, 1999 - Google Patents
Modified oligonucleotides 3'-NHP (O)(O) O-5'phosphora midates were synthesized on a
solid phase Support. The phosphoramidate analogs were found to have significantly …
solid phase Support. The phosphoramidate analogs were found to have significantly …
Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation
G Wang, DD Levy, MM Seidman… - Molecular and cellular …, 1995 - Am Soc Microbiol
As an alternative to standard gene transfer techniques for genetic manipulation, we have
investigated the use of triple helix-forming oligonucleotides to target mutations to selected …
investigated the use of triple helix-forming oligonucleotides to target mutations to selected …
Oligonucleotide N3′→ N5′ Phosphoramidate Duplexes
SM Gryaznov, RG Schultz, J Chen - US Patent 6,169,170, 2001 - Google Patents
Abstract Modified oligonucleotides 3′-NHP (O)(O−) O-5′ phosphoramidates were
synthesized on a solid phase support. The phosphoramidate analogs were found to have …
synthesized on a solid phase support. The phosphoramidate analogs were found to have …
Sticky DNA, a self-associated complex formed at long GAA· TTC repeats in intron 1 of the frataxin gene, inhibits transcription
N Sakamoto, K Ohshima, L Montermini… - Journal of Biological …, 2001 - ASBMB
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by
the expansion of GAA· TTC repeats in the first intron of the frataxin (X25) gene. FRDA …
the expansion of GAA· TTC repeats in the first intron of the frataxin (X25) gene. FRDA …