The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention
and rehabilitation requires frequent update of existing guidelines. This review is aimed at …

Tuberculosis is the leading cause of deaths from an infectious disease worldwide. WHO's
End TB Strategy is falling short of several 2020 targets. Undernutrition is the leading …

BACKGROUND: Optimal drug dosing is important to ensure adequate response to
treatment, prevent development of drug resistance and reduce drug toxicity. The aim of …

Tuberculosis (TB) is still the number one cause of death due to an infectious disease.
Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB …

There has been an increased interest in pharmacokinetics and pharmacodynamics (PKPD)
of anti-tuberculosis drugs. A better understanding of the relationship between drug …

Introduction Tuberculosis requires lengthy multi-drug therapy. Mycobacterium tuberculosis
occupies different tissue compartments during infection, making drug access and …

Background Suboptimal exposure to antituberculosis (anti-TB) drugs has been associated
with unfavourable treatment outcomes. We aimed to investigate estimates and determinants …

Background Prospective studies correlating pharmacokinetic/pharmacodynamic (PK/PD)
indices to clinical responses are urgently needed. This study aimed to find clinically relevant …

Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to pose a significant
threat to global health. The resilience of TB is amplified by a myriad of physical, biological …

Background Understanding the impact of drug exposure and susceptibility on treatment
response of multidrug-resistant tuberculosis (MDR-TB) will help to optimise treatment. This …