Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Autism spectrum disorder

C Lord, TS Brugha, T Charman, J Cusack… - Nature reviews Disease …, 2020 - nature.com
Autism spectrum disorder is a construct used to describe individuals with a specific
combination of impairments in social communication and repetitive behaviours, highly …

Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder

Z Dan, X Mao, Q Liu, M Guo, Y Zhuang, Z Liu… - Gut …, 2020 - Taylor & Francis
ABSTRACT Autism Spectrum Disorder (ASD) is a severe neurodevelopmental disorder. To
enhance the understanding of the gut microbiota structure in ASD children at different ages …

Human cerebral organoids—a new tool for clinical neurology research

OL Eichmüller, JA Knoblich - Nature Reviews Neurology, 2022 - nature.com
The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures

L Qin, JB Williams, T Tan, T Liu, Q Cao, K Ma… - Nature …, 2021 - nature.com
ASH1L, a histone methyltransferase, is identified as a top-ranking risk factor for autism
spectrum disorder (ASD), however, little is known about the biological mechanisms …

Novel treatments in autism spectrum disorder

D Baribeau, J Vorstman… - Current Opinion in …, 2022 - journals.lww.com
Recent data support the use of behavioural and psychological interventions for social
communication and anxiety in ASD; data are more limited regarding pharmacotherapy for …

[HTML][HTML] Novel treatments for autism spectrum disorder based on genomics and systems biology

D Baribeau, E Anagnostou - Pharmacology & therapeutics, 2022 - Elsevier
Background Autism spectrum disorder (ASD) is a highly heterogeneous
neurodevelopmental disorder with a complex underlying genetic architecture. There are …

[HTML][HTML] Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review

NF Parrella, AT Hill, LM Dipnall, YJ Loke… - Journal of Psychiatric …, 2024 - Elsevier
The primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) has a prominent role in
regulating neural development and function, with disruption to GABAergic signalling linked …

NLRP3–GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice

LY Wang, XP Wang, JM Lv, YD Shan, SY Jia… - Journal of …, 2023 - Springer
Background Perioperative neurocognitive disorders (PND), such as delirium and cognitive
impairment, are commonly encountered complications in aged patients. The inhibitory …

The cortico-striatal circuitry in autism-spectrum disorders: a balancing act

JJ Soghomonian - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
The basal ganglia are major targets of cortical inputs and, in turn, modulate cortical function
via their projections to the motor and prefrontal cortices. The role of the basal ganglia in …