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Understanding plant stress memory response for abiotic stress resilience: Molecular insights and prospects
As sessile species and without the possibility of escape, plants constantly face numerous
environmental stresses. To adapt in the external environmental cues, plants adjust …
environmental stresses. To adapt in the external environmental cues, plants adjust …
Epigenetic and chromatin-based mechanisms in environmental stress adaptation and stress memory in plants
Plants frequently have to weather both biotic and abiotic stressors, and have evolved
sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications …
sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications …
FUS and TDP-43 phases in health and disease
The distinct prion-like domains (PrLDs) of FUS and TDP-43, modulate phase transitions that
result in condensates with a range of material states. These assemblies are implicated in …
result in condensates with a range of material states. These assemblies are implicated in …
The causes of evolvability and their evolution
Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …
heritable and adaptive. It has long been the subject of anecdotal observations and …
Generic nature of the condensed states of proteins
Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …
rate. Since at the high concentrations present in the cell most proteins would be expected to …
Protein-based inheritance: epigenetics beyond the chromosome
Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. This
phenomenon has largely been studied in the context of chromatin modification. Yet many …
phenomenon has largely been studied in the context of chromatin modification. Yet many …
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Understanding how microbial pathogens adapt to treatments, humans and clinical
environments is key to infer mechanisms of virulence, transmission and drug resistance …
environments is key to infer mechanisms of virulence, transmission and drug resistance …
Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior
Many proteins, such as RNA-binding proteins, have complex folding landscapes. How cells
maintain the solubility and folding state of such proteins, particularly under stress conditions …
maintain the solubility and folding state of such proteins, particularly under stress conditions …
[HTML][HTML] Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation
The transition between the native and amyloid states of proteins can proceed via a
deposition pathway via oligomeric intermediates or via a condensation pathway involving …
deposition pathway via oligomeric intermediates or via a condensation pathway involving …
Protein phase separation as a stress survival strategy
Cells under stress must adjust their physiology, metabolism, and architecture to adapt to the
new conditions. Most importantly, they must down-regulate general gene expression, but at …
new conditions. Most importantly, they must down-regulate general gene expression, but at …