Radioimmunotherapy with alpha-emitting nuclides
This review discusses the application of alpha particle-emitting radionuclides in targeted
radioimmunotherapy. It will outline the production and chemistry of astatine-211, bismuth …
radioimmunotherapy. It will outline the production and chemistry of astatine-211, bismuth …
Actinium-225 in targeted alpha-particle therapeutic applications
DA Scheinberg, MR McDevitt - Current radiopharmaceuticals, 2011 - ingentaconnect.com
Alpha particle-emitting isotopes are being investigated in radioimmunotherapeutic
applications because of their unparalleled cytotoxicity when targeted to cancer and their …
applications because of their unparalleled cytotoxicity when targeted to cancer and their …
Actinium-225 for targeted α therapy: coordination chemistry and current chelation approaches
The α-emitting radionuclide actinium-225 possesses nuclear properties that are highly
promising for use in targeted α therapy (TAT), a therapeutic strategy that employs α particle …
promising for use in targeted α therapy (TAT), a therapeutic strategy that employs α particle …
Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications
M Miederer, DA Scheinberg, MR McDevitt - Advanced drug delivery reviews, 2008 - Elsevier
Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for
augmenting targeted therapy. Properties of alpha particle radiation such as their limited …
augmenting targeted therapy. Properties of alpha particle radiation such as their limited …
[HTML][HTML] Advances in targeted alpha therapy for prostate cancer
Amongst therapeutic radiopharmaceuticals, targeted alpha therapy (TαT) can deliver potent
and local radiation selectively to cancer cells as well as the tumor microenvironment and …
and local radiation selectively to cancer cells as well as the tumor microenvironment and …
Trace elements and their isotopes in bones and teeth: Diet, environments, diagenesis, and dating of archeological and paleontological samples
Fossil biogenic apatites display trace element (TE) compositions that can record
environmental and biological signals, give insights into past water compositions, or be used …
environmental and biological signals, give insights into past water compositions, or be used …
The in vivo fate of 225Ac daughter nuclides using polymersomes as a model carrier
RM Kruijff, R Raavé, A Kip, J Molkenboer-Kuenen… - Scientific reports, 2019 - nature.com
Increasing attention is given to personalized tumour therapy, where α-emitters can
potentially play an important role. Alpha particles are ideal for localized cell killing because …
potentially play an important role. Alpha particles are ideal for localized cell killing because …
CERN-MEDICIS (medical isotopes collected from ISOLDE): a new facility
RMS Augusto, L Buehler, Z Lawson, S Marzari… - Applied Sciences, 2014 - mdpi.com
About 50% of the 1.4 GeV CERN (European Organization for Nuclear Research, www. cern.
ch) protons are sent onto targets to produce radioactive beams by online mass separation at …
ch) protons are sent onto targets to produce radioactive beams by online mass separation at …
Improved in vivo stability of actinium-225 macrocyclic complexes
KA Deal, IA Davis, S Mirzadeh, SJ Kennel… - Journal of medicinal …, 1999 - ACS Publications
The favorable nuclear properties of actinium-225 (225Ac) have led to proposal of this
isotope for use in radioimmunotherapy. In an effort to reduce the toxicity of free 225Ac, a …
isotope for use in radioimmunotherapy. In an effort to reduce the toxicity of free 225Ac, a …
Targeted alpha therapy in vivo: direct evidence for single cancer cell kill using 149Tb-rituximab
GJ Beyer, M Miederer, S Vranješ-Đurić… - European journal of …, 2004 - Springer
This study demonstrates high-efficiency sterilisation of single cancer cells in a SCID mouse
model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with …
model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with …