The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Background Assessments of age-specific mortality and life expectancy have been done by
the UN Population Division, Department of Economics and Social Affairs (UNPOP), the …

While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …

We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …

Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …

High fidelity (HF) mathematical models describing the generation of active force in the
cardiac muscle tissue typically feature a large number of state variables to capture the …

In this work, we present a fully coupled fluid‐electro‐mechanical model of a 50th percentile
human heart. The model is implemented on Alya, the BSC multi‐physics parallel code …