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Dopamine: the neuromodulator of long-term synaptic plasticity, reward and movement control
Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions
including motor control, modulation of affective and emotional states, reward mechanisms …
including motor control, modulation of affective and emotional states, reward mechanisms …
Mechanisms of cognitive dysfunction in CKD
Cognitive impairment is an increasingly recognized major cause of chronic disability and is
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …
Molecular networks in Network Medicine: Development and applications
Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives
Mammals expend energy in many ways, including basic cellular maintenance and repair,
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with
limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal …
limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal …
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
L Wen, YS Lu, XH Zhu, XM Li, RS Woo… - Proceedings of the …, 2010 - pnas.org
Neuregulin 1 (NRG1) is a trophic factor thought to play a role in neural development. Recent
studies suggest that it may regulate neurotransmission, mechanisms of which remain …
studies suggest that it may regulate neurotransmission, mechanisms of which remain …
Performance of male and female C57BL/6J mice on motor and cognitive tasks commonly used in pre-clinical traumatic brain injury research
To date, clinical trials have failed to find an effective therapy for victims of traumatic brain
injury (TBI) who live with motor, cognitive, and psychiatric complaints. Pre-clinical …
injury (TBI) who live with motor, cognitive, and psychiatric complaints. Pre-clinical …
Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities
Rett syndrome (RTT) is characterized by specific motor, cognitive, and behavioral deficits.
Because several of these abnormalities occur in other disease states associated with …
Because several of these abnormalities occur in other disease states associated with …
Does the difference between physically active and couch potato lie in the dopamine system?
Obesity and other inactivity related diseases are increasing at an alarming rate especially in
Western societies. Because of this, it is important to understand the regulating mechanisms …
Western societies. Because of this, it is important to understand the regulating mechanisms …
Neuropsychiatric symptom modeling in male and female C57BL/6J mice after experimental traumatic brain injury
Psychiatric symptoms such as anxiety and depression are frequent and persistent
complaints following traumatic brain injury (TBI). Modeling these symptoms in animal …
complaints following traumatic brain injury (TBI). Modeling these symptoms in animal …