Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

The precise characterization of oxygen-sensing pathways and the identification of pO2-
regulated gene expression are both issues of critical importance. The O2-sensing system …

Recent studies suggested that prolyl hydroxylase 2 (PHD2) functions as an important
regulator in vascular inflammation and Streptococcus pneumonia infection. However …

Hypoxia-inducible factor-1α (HIF-1α)-dependent liver-metastasis-related factor expression
mediates breast cancer liver invasion and metastasis, so downregulation of HIF-1α is of …

In oxygen-deprived conditions, cells respond by activating adaptive mechanisms to bolster
their survival and protect tissue integrity. A key player in this process is the HIF-1α signaling …

Familiar cancers represent a privileged point of view for studying the complex cellular events
inducing tumor transformation. Von Hippel-Lindau syndrome, a familiar predisposition to …

We aimed to examine the therapeutic potential of polysaccharide H-1-2, a bioactive
component of Pseudostellaria heterophylla, against pancreatic cancer, as well as to …

The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as
master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is …

Background/Aims: To investigate the potential therapeutic effect of novel polysaccharide H-1-
2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate …

The contribution of nutritional factors to disease development has been demonstrated for
several chronic conditions including obesity, type 2 diabetes, metabolic syndrome, and …