Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …

Metabolic reprogramming in a subpopulation of cancer cells is a hallmark of tumor
chemoresistance. However, single-cell metabolic profiling is difficult because of the lack of a …

Lipid metabolic reprogramming is an established trait of cancer metabolism that guides
response and resistance to antitumoral therapies. Enhanced lipogenesis, increased lipid …

Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …

Abstract Mitochondria-associated membranes (MAM), physical platforms that enable
communication between mitochondria and the endoplasmic reticulum (ER), are enriched …

Cellular imaging is an active area of research that enables researchers to monitor cellular
dynamics, as well as responses to various external stimuli (physiological stress, exogenous …