Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
Aging and rejuvenation of neural stem cells and their niches
Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …
declining cognitive function and enhanced risk of brain diseases, including cancer and …
Neurogenesis in aging and age-related neurodegenerative diseases
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …
adult brain, declines in an age-dependent manner and is one potential target for extending …
[HTML][HTML] Current state of stem cell-based therapies: an overview
RM Aly - Stem cell investigation, 2020 - ncbi.nlm.nih.gov
Recent research reporting successful translation of stem cell therapies to patients have
enriched the hope that such regenerative strategies may one day become a treatment for a …
enriched the hope that such regenerative strategies may one day become a treatment for a …
Cell therapy for neurological disorders
SP Svendsen, CN Svendsen - Nature Medicine, 2024 - nature.com
Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …
challenges and opportunities compared with conventional medicines. They have the …
Advances in nanomedicines for diagnosis of central nervous system disorders
In spite of a great improvement in medical health services and an increase in lifespan, we
have witnessed a skyrocket increase in the incidence of central nervous system (CNS) …
have witnessed a skyrocket increase in the incidence of central nervous system (CNS) …
Effects of neural stem cell transplantation in Alzheimer's disease models
Y Hayashi, HT Lin, CC Lee, KJ Tsai - Journal of biomedical science, 2020 - Springer
Currently there are no therapies for treating Alzheimer's disease (AD) that can effectively halt
disease progression. Existing drugs such as acetylcholinesterase inhibitors or NMDA …
disease progression. Existing drugs such as acetylcholinesterase inhibitors or NMDA …
[HTML][HTML] Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier
Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60–70%
of all cases. It affects millions of people worldwide. AD poses a substantial economic burden …
of all cases. It affects millions of people worldwide. AD poses a substantial economic burden …
[HTML][HTML] Neural stem cell therapy for neurovascular injury in Alzheimer's disease
AC Boese, MH Hamblin, JP Lee - Experimental neurology, 2020 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
progressive neurodegeneration leading to severe cognitive decline and eventual death. AD …
progressive neurodegeneration leading to severe cognitive decline and eventual death. AD …
Intranasal transplantation of human neural stem cells ameliorates Alzheimer's disease-like pathology in a mouse model
MH Lu, WL Ji, H Chen, YY Sun, XY Zhao… - Frontiers in Aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory
impairments, which has no effective therapy. Stem cell transplantation shows great potential …
impairments, which has no effective therapy. Stem cell transplantation shows great potential …