Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology

K Gouveia-Freitas, AJ Bastos-Leite - Neuroradiology, 2021 - Springer
Perivascular spaces (PVS) of the brain, often called Virchow-Robin spaces, comprise fluid,
cells and connective tissue, and are externally limited by astrocytic endfeet. PVS are …

[HTML][HTML] Imaging perivascular space structure and function using brain MRI

G Barisano, KM Lynch, F Sibilia, H Lan, NC Shih… - Neuroimage, 2022 - Elsevier
In this article, we provide an overview of current neuroimaging methods for studying
perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing …

Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms

A Rau, N Schroeter, G Blazhenets, A Dressing… - Brain, 2022 - academic.oup.com
While neuropathological examinations in patients who died from COVID-19 revealed
inflammatory changes in cerebral white matter, cerebral MRI frequently fails to detect …

Perivascular spaces, glymphatic system and MR

L Yu, X Hu, H Li, Y Zhao - Frontiers in Neurology, 2022 - frontiersin.org
The importance of the perivascular space (PVS) as one of the imaging markers of cerebral
small vessel disease (CSVD) has been widely appreciated by the neuroradiologists. The …

[HTML][HTML] Neuroimaging at 7 Tesla: a pictorial narrative review

T Okada, K Fujimoto, Y Fushimi, T Akasaka… - … imaging in medicine …, 2022 - ncbi.nlm.nih.gov
Abstract Neuroimaging using the 7-Tesla (7T) human magnetic resonance (MR) system is
rapidly gaining popularity after being approved for clinical use in the European Union and …

Blood–brain barrier disruption and perivascular spaces in small vessel disease and neurodegenerative diseases: a review on MRI methods and insights

PHM Voorter, M van Dinther, WJ Jansen… - Journal of Magnetic …, 2024 - Wiley Online Library
Perivascular spaces (PVS) and blood–brain barrier (BBB) disruption are two key features of
cerebral small vessel disease (cSVD) and neurodegenerative diseases that have been …

[HTML][HTML] Brain perivascular space imaging across the human lifespan

KM Lynch, F Sepehrband, AW Toga, J Choupan - Neuroimage, 2023 - Elsevier
Enlarged perivascular spaces (PVS) are considered a biomarker for vascular pathology and
are observed in normal aging and neurological conditions; however, research on the role of …

A critical guide to the automated quantification of perivascular spaces in magnetic resonance imaging

W Pham, M Lynch, G Spitz, T O'Brien… - Frontiers in …, 2022 - frontiersin.org
The glymphatic system is responsible for waste clearance in the brain. It is comprised of
perivascular spaces (PVS) that surround penetrating blood vessels. These spaces are filled …

Brain Injury: Response to Injury Wound-Healing Mechanisms and Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

MR Hayden - Medicina, 2023 - mdpi.com
Embryonic genetic mechanisms are present in the brain and ready to be placed into action
upon cellular injury, termed the response to injury wound-healing (RTIWH) mechanism …

The glymphatic system in migraine and other headaches

MG Vittorini, A Sahin, A Trojan, S Yusifli… - The Journal of …, 2024 - Springer
Glymphatic system is an emerging pathway of removing metabolic waste products and toxic
solutes from the brain tissue. It is made of a network of perivascular spaces, filled in …