Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in cancer development and prevention

R Mirzaei, A Afaghi, S Babakhani, MR Sohrabi… - Biomedicine & …, 2021 - Elsevier
Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …

Secondary osteoporosis

PR Ebeling, HH Nguyen, J Aleksova… - Endocrine …, 2022 - academic.oup.com
Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

[HTML][HTML] Antibiotics for cancer treatment: A double-edged sword

Y Gao, Q Shang, W Li, W Guo, A Stojadinovic… - Journal of …, 2020 - ncbi.nlm.nih.gov
Various antibiotics have been used in the treatment of cancers, via their anti-proliferative,
pro-apoptotic and anti-epithelial-mesenchymal-transition (EMT) capabilities. However …

The human gut microbiota: a key mediator of osteoporosis and osteogenesis

KD Seely, CA Kotelko, H Douglas, B Bealer… - International journal of …, 2021 - mdpi.com
An expanding body of research asserts that the gut microbiota has a role in bone
metabolism and the pathogenesis of osteoporosis. This review considers the human gut …

[HTML][HTML] Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis

J He, S Xu, B Zhang, C **ao, Z Chen, F Si, J Fu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Reduced bone mineral density (BMD) is associated with an altered microbiota in senile
osteoporosis. However, the relationship among gut microbiota, BMD and bone metabolic …

[HTML][HTML] Engineered bacterial extracellular vesicles for osteoporosis therapy

H Liu, M Li, T Zhang, X Liu, H Zhang, Z Geng… - Chemical Engineering …, 2022 - Elsevier
Osteoporosis (OP) is a systemic bone disease characterized by reduction of bone mass and
destruction of structure, which can easily lead to fragility fractures. Over the past decade, an …

The microbiota-gut-bone axis and bone health

Y Tu, R Yang, X Xu, X Zhou - Journal of leukocyte biology, 2021 - academic.oup.com
The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria,
fungi, and viruses, known as the “second gene pool” of the human body. In recent years, the …

The role of gut microbiota in bone homeostasis

J Behera, J Ison, SC Tyagi, N Tyagi - Bone, 2020 - Elsevier
The gut microbiota (GM) is referred to as the second gene pool of the human body and a
commensal, symbiotic, and pathogenic microorganism living in our intestines. The …

[HTML][HTML] Bone-targeted engineered bacterial extracellular vesicles delivering miRNA to treat osteoporosis

H Liu, Y Wu, F Wang, S Wang, N Ji, M Wang… - Composites Part B …, 2023 - Elsevier
Osteoporosis (OP), characterized by decreased bone density and destruction of bone
microstructure, is a common systemic bone disease in the elderly. Conventional therapies …