Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

KP De Sousa, I Rossi, M Abdullahi… - Wiley …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer
nanoparticles secreted by most cells. EVs are regarded as important mediators of …

Extracellular‐vesicle‐based drug delivery systems for enhanced antitumor therapies through modulating the cancer‐immunity cycle

T Yong, Z Wei, L Gan, X Yang - Advanced Materials, 2022 - Wiley Online Library
Although immunotherapy harnessing activity of the immune system against tumors has
made great progress, the treatment efficacy remains limited in most cancers. Current …

Evolution of drug delivery systems: From 1950 to 2020 and beyond

H Park, A Otte, K Park - Journal of Controlled Release, 2022 - Elsevier
Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …

Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis

L Tong, S Zhang, Q Liu, C Huang, H Hao, MS Tan… - Science …, 2023 - science.org
Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine
for intestinal disorders; however, their impact on intestinal barrier integrity in gut …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Biomembrane-based nanostructures for cancer targeting and therapy: from synthetic liposomes to natural biomembranes and membrane-vesicles

J Wang, M Zhu, G Nie - Advanced drug delivery reviews, 2021 - Elsevier
The translational success of liposomes in chemotherapeutics has already demonstrated the
great potential of biomembrane-based nanostructure in effective drug delivery. Meanwhile …

Anticancer therapy targeting cancer-derived extracellular vesicles

X Cheng, BS Henick, K Cheng - ACS nano, 2024 - ACS Publications
Extracellular vesicles (EVs) are natural lipid nanoparticles secreted by most types of cells. In
malignant cancer, EVs derived from cancer cells contribute to its progression and metastasis …

Immune checkpoint inhibition in GBM primed with radiation by engineered extracellular vesicles

T Tian, R Liang, G Erel-Akbaba, L Saad, PJ Obeid… - ACS …, 2022 - ACS Publications
The lack of safe and effective delivery across the blood-brain barrier and the profound
immune suppressive microenvironment are two main hurdles to glioblastoma (GBM) …

[HTML][HTML] Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges

T Skotland, TG Iversen, A Llorente, K Sandvig - Advanced drug delivery …, 2022 - Elsevier
There is a large interest in develo** nanoparticles and extracellular vesicles for delivery of
therapeutics or imaging agents. Regulatory approval of such products requires knowledge …

A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy

M Van Delen, J Derdelinckx, K Wouters… - Journal of …, 2024 - Wiley Online Library
Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste
disposal vesicle but are an essential part of an intercellular communication system. Besides …