Pharmaceutical co-crystals
P Vishweshwar, JA McMahon, JA Bis… - Journal of …, 2006 - Elsevier
Crystal engineering has evolved in such a manner that it is now synonymous with the
paradigm of supramolecular synthesis, that is, it invokes self-assembly of existing molecules …
paradigm of supramolecular synthesis, that is, it invokes self-assembly of existing molecules …
Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
Pharmaceutical cocrystals: along the path to improved medicines
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …
from crystal engineers and pharmaceutical scientists in the past decade and are now an …
Use of a glutaric acid cocrystal to improve oral bioavailability of a low solubility API
DP McNamara, SL Childs, J Giordano, A Iarriccio… - Pharmaceutical …, 2006 - Springer
Purpose The bioavailability of a development candidate active pharmaceutical ingredient
(API) was very low after oral dosing in dogs. In order to improve bioavailability, we sought to …
(API) was very low after oral dosing in dogs. In order to improve bioavailability, we sought to …
Hierarchy of supramolecular synthons: persistent carboxylic acid··· pyridine hydrogen bonds in cocrystals that also contain a hydroxyl moiety
A Cambridge Structural Database (CSD) analysis was conducted in order to evaluate the
hierarchy of supramolecular heterosynthons that involve two of the most relevant functional …
hierarchy of supramolecular heterosynthons that involve two of the most relevant functional …
Synthesis and structural characterization of cocrystals and pharmaceutical cocrystals: mechanochemistry vs slow evaporation from solution
DR Weyna, T Shattock, P Vishweshwar… - Crystal Growth and …, 2009 - ACS Publications
The reliability of solvent drop grinding (SDG), also referred to as liquid assisted grinding, wet
cogrinding, or mechanochemistry, to facilitate cocrystal formation is addressed with a series …
cogrinding, or mechanochemistry, to facilitate cocrystal formation is addressed with a series …
Tape and layer structures in cocrystals of some di-and tricarboxylic acids with 4, 4′-bipyridines and isonicotinamide. From binary to ternary cocrystals
Linear, zigzag tapes and flat, corrugated sheet structures are described in binary cocrystals
1–9 of some di-and tricarboxylic acids with 4, 4′-bipyridine bases and isonicotinamide …
1–9 of some di-and tricarboxylic acids with 4, 4′-bipyridine bases and isonicotinamide …
Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies
Design and synthesis of pharmaceutical cocrystals have received great interest in recent
years. Cocrystallization of drug substances offers a tremendous opportunity for the …
years. Cocrystallization of drug substances offers a tremendous opportunity for the …
Structure− stability relationships in cocrystal hydrates: Does the promiscuity of water make crystalline hydrates the nemesis of crystal engineering?
This contribution addresses the role of water molecules in crystal engineering by studying
the crystal structures and thermal stabilities of 11 new cocrystal hydrates, all of which were …
the crystal structures and thermal stabilities of 11 new cocrystal hydrates, all of which were …
Controlling polymorphism in molecular cocrystals by variable temperature ball milling
K Linberg, B Röder, D Al-Sabbagh, F Emmerling… - Faraday …, 2023 - pubs.rsc.org
Mechanochemistry offers a unique opportunity to modify and manipulate crystal forms, often
providing new products as compared with conventional solution methods. While promising …
providing new products as compared with conventional solution methods. While promising …