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Features and applications of haplotypes in crop breeding
Climate change with altered pest-disease dynamics and rising abiotic stresses threatens
resource-constrained agricultural production systems worldwide. Genomics-assisted …
resource-constrained agricultural production systems worldwide. Genomics-assisted …
Genotype imputation for genome-wide association studies
In the past few years genome-wide association (GWA) studies have uncovered a large
number of convincingly replicated associations for many complex human diseases …
number of convincingly replicated associations for many complex human diseases …
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity
varies between individuals, and immune responses correlate with vaccine efficacy. Using …
varies between individuals, and immune responses correlate with vaccine efficacy. Using …
Reference-based phasing using the Haplotype Reference Consortium panel
Haplotype phasing is a fundamental problem in medical and population genetics. Phasing is
generally performed via statistical phasing in a genotyped cohort, an approach that can yield …
generally performed via statistical phasing in a genotyped cohort, an approach that can yield …
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
Widely used as anticancer and immunosuppressive agents, thiopurines have narrow
therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic …
therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic …
A linear complexity phasing method for thousands of genomes
Human-disease etiology can be better understood with phase information about diploid
sequences. We present a method for estimating haplotypes, using genotype data from …
sequences. We present a method for estimating haplotypes, using genotype data from …
The relative power of genome scans to detect local adaptation depends on sampling design and statistical method
Although genome scans have become a popular approach towards understanding the
genetic basis of local adaptation, the field still does not have a firm grasp on how sampling …
genetic basis of local adaptation, the field still does not have a firm grasp on how sampling …
A general approach for haplotype phasing across the full spectrum of relatedness
Many existing cohorts contain a range of relatedness between genotyped individuals, either
by design or by chance. Haplotype estimation in such cohorts is a central step in many …
by design or by chance. Haplotype estimation in such cohorts is a central step in many …
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
The intestinal microflora, typically equated with bacteria, influences diseases such as
obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a …
obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a …
The genome of the domesticated apple (Malus × domestica Borkh.)
We report a high-quality draft genome sequence of the domesticated apple (Malus×
domestica). We show that a relatively recent (> 50 million years ago) genome-wide …
domestica). We show that a relatively recent (> 50 million years ago) genome-wide …