YAP/TAZ at the roots of cancer
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
Mechanisms of Hippo pathway regulation
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …
growth two decades ago and has been a subject extensively studied in both Drosophila and …
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis
H Zhou, M Wang, Y Zhang, Q Su, Z **e… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
The role of YAP/TAZ activity in cancer metabolic reprogramming
X Zhang, H Zhao, Y Li, D **a, L Yang, Y Ma, H Li - Molecular cancer, 2018 - Springer
In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy
production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth …
production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth …
Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP‐TEAD complex
H Wei, F Wang, Y Wang, T Li, P **u, J Zhong… - Cancer …, 2017 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human
malignancies. The Yes‐associated protein‐1 (YAP) plays a critical role in cell proliferation …
malignancies. The Yes‐associated protein‐1 (YAP) plays a critical role in cell proliferation …
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
O Dobrokhotov, M Samsonov, M Sokabe… - Clinical and translational …, 2018 - Springer
Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator
1 (TAZ) are important regulators of multiple cellular functions such as proliferation …
1 (TAZ) are important regulators of multiple cellular functions such as proliferation …
WW domain-containing proteins YAP and TAZ in the hippo pathway as key regulators in stemness maintenance, tissue homeostasis, and tumorigenesis
YA Chen, CY Lu, TY Cheng, SH Pan, HF Chen… - Frontiers in …, 2019 - frontiersin.org
The Hippo pathway is a conserved signaling pathway originally defined in Drosophila
melanogaster two decades ago. Deregulation of the Hippo pathway leads to significant …
melanogaster two decades ago. Deregulation of the Hippo pathway leads to significant …
YAP/TAZ activation as a target for treating metastatic cancer
Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …
have both emerged as important drivers of cancer progression and metastasis. YAP and …
A potential role of YAP/TAZ in the interplay between metastasis and metabolic alterations
H Yamaguchi, GM Taouk - Frontiers in oncology, 2020 - frontiersin.org
Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …
Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival
E Rozengurt, J Sinnett-Smith, G Eibl - Signal transduction and targeted …, 2018 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious
treatment modalities. Elucidation of signaling mechanisms that will lead to the identification …
treatment modalities. Elucidation of signaling mechanisms that will lead to the identification …