One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

Neuroimaging has revealed robust interactions between the prefrontal cortex and the
hippocampus when people stop memory retrieval. Efforts to stop retrieval can arise when …

Recent and pioneering animal research has revealed the brain utilizes a variety of
molecular, cellular, and network-level mechanisms used to forget memories in a process …

The brain has a remarkable but underappreciated capacity to limit memory formation and
expression. The term" memory suppressor gene" was coined in 1998 as an attempt to …

Abstract The dynorphin (DYN)/kappa-opioid receptor (KOR) system is involved in dysphoria
and negative emotional states. Dysregulation of KOR function promotes maladaptive …

Chronic relapse is a hallmark of substance-use disorders (SUDs), but many people with
SUDs do recover and eventually enter remission. Many preclinical studies in this field aim to …

Premature reproductive aging is linked to heightened stress sensitivity and psychological
maladjustment across the life course. However, the brain dynamics underlying this …

Abstract Background and Purpose Tetrabenazine (TBZ), used for treating hyperkinetic
disorders, inhibits vesicular monoamine transporter‐2 (VMAT‐2), which sequesters …

Studies have shown that spaceflight affects the emotional and social performance of
astronauts. Identifying the neural mechanisms underlying the emotional and social effects of …

Prepulse inhibition (PPI) is a crucial indicator of sensorimotor gating that is often impaired in
neuropsychiatric diseases. Although dopamine D1 receptor agonists have been found to …