Inflammation is a physiological mechanism used by organisms to defend themselves
against infection, restoring homeostasis in damaged tissues. It represents the starting point …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Abstract Background Helminth extracellular vesicles (EVs) are known to have a three-way
communication function among parasitic helminths, their host and the host-associated …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

M1 aminopeptidase is a metallopeptidase that plays a vital role in protein catabolism and
has been identified as a validated drug target in various parasites; however, our …

The endoplasmic-reticulum aminopeptidase ERAP1 processes antigenic peptides for
loading on MHC-I proteins and recognition by CD8 T cells as they survey the body for …

ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important
role in the immune system by trimming peptides for loading onto major histocompatibility …

The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets,
including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP2) and insulin …

Insulin-Regulated Aminopeptidase (IRAP, EC 3.4. 11.3) is a multi-tasking member of the M1
family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of …

The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, Pf
M1AAP and Pf M17LAP, are potential targets for novel anti-malarial drug development …