Neurons are highly polarized cells with elaborate shapes that allow them to perform their
function. In neurons, microtubule organization—length, density, and dynamics—are …

Spinal muscular atrophy (SMA) is an uncommon disorder associated with genes
characterized by the gradual weakening and deterioration of muscles, often leading to …

The mammalian nervous system is made up of an extraordinary array of diverse cells that
form intricate functional connections. The programs underlying cell lineage specification …

Molecular pathways that intrinsically regulate neuronal maintenance are poorly understood,
but rare pathogenic mutations that underlie neurodegenerative disease can offer important …

Inherited forms of motor neuron disease (MND), including hereditary spastic paraplegias
(HSP), are associated with the death or dysfunction of nerve cells that control skeletal …

Abstract ALS (Amyotrophic Lateral Sclerosis) is a fatal neurodegenerative disease of the
human motor system. It is a group of progressive diseases that affects the nerve cells in the …

The wobbler mouse is a widely used model system of amyotrophic lateral sclerosis and
exhibits progressive neurodegeneration and neuroinflammation in association with skeletal …

Background: Inherited pediatric motor neuron diseases (MNDs) are a group of
neurodegenerative disorders characterized by the degeneration of motor neurons in the …

Amyotrophic lateral sclerosis (ALS), a complicated neurodegenerative disorder affected by
hereditary and environmental variables, is a condition. In this study, the genetic makeup of …

Abstract Introduction/Aims Genetics is an important risk factor for amyotrophic lateral
sclerosis (ALS), a neurodegenerative disease affecting motor neurons. Recent findings …