Autoimmune diseases are associated with a dramatically increased risk of atherosclerotic
cardiovascular disease and its clinical manifestations. The increased risk is consistent with …

Advances in cancer therapeutics have improved patient survival rates. However, cancer
survivors may suffer from adverse events either at the time of therapy or later in life …

Objective Macrophage polarization and the resulting phenotype have versatile roles in
atherosclerosis. The study aims to decipher the role of SIRT1 in regulating macrophage …

Antibodies are essential to immune homeostasis due to their roles in neutralizing
pathogenic agents. However, failures in central and peripheral checkpoints that eliminate …

Vaccination with self-and foreign peptides induces weak and strong expansion of antigen-
specific CD4+ T cells, respectively, but the mechanism is not known. In the present study, we …

A healthy immune system is tolerant to self-antigens while maintaining responsiveness to
foreign threats. Co-expression of the inhibitory receptors PD-1 and CD73 regulates …

A right-side-out orientated self-assembly of cell membrane-camouflaged theranostic
nanoplatform is crucial for ensuring their biological functionality inherited from the source …

Ischaemic heart disease is a consequence of coronary atherosclerosis, and atherosclerosis
is a systemic inflammatory disease. The spleen releases various immune cells in temporally …

The onset of atherosclerosis (AS) is insidious, and early stage patients have atypical clinical
symptoms. After being diagnosed in late stage, it is often prone to sudden and fatal …

This paper investigates the therapeutic use of PCSK9 inhibitors, particularly Evolocumab, as
monoclonal antibodies for the treatment of atherosclerosis based on recent literature …