The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery
Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …
clarifying their nature, identifying their biological underpinnings, and determining their …
Probing neural circuit mechanisms in Alzheimer's disease using novel technologies
The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new …
mechanisms that has guided therapies that attenuate neuropathological features. A new …
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
MR Chuapoco, NC Flytzanis, N Goeden… - Nature …, 2023 - nature.com
Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the
brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the …
brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the …
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Seizures are made up of the coordinated activity of networks of neurons, suggesting that
control of neurons in the pathologic circuits of epilepsy could allow for control of the disease …
control of neurons in the pathologic circuits of epilepsy could allow for control of the disease …
Spatial transcriptomics for profiling the tropism of viral vectors in tissues
A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders
J El Andari, E Renaud-Gabardos, W Tulalamba… - Science …, 2022 - science.org
Bioengineering of viral vectors for therapeutic gene delivery is a pivotal strategy to reduce
doses, facilitate manufacturing, and improve efficacy and patient safety. Here, we …
doses, facilitate manufacturing, and improve efficacy and patient safety. Here, we …
A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes
associated with persistent pain. Chemogenetics has shown promise as a means to suppress …
associated with persistent pain. Chemogenetics has shown promise as a means to suppress …
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors
The blood-brain barrier (BBB) presents a major challenge for delivering large molecules to
study and treat the central nervous system. This is due in part to the scarcity of targets known …
study and treat the central nervous system. This is due in part to the scarcity of targets known …
The role of cellular and molecular neuroimmune crosstalk in gut immunity
The gastrointestinal tract is densely innervated by the peripheral nervous system and
populated by the immune system. These two systems critically coordinate the sensations of …
populated by the immune system. These two systems critically coordinate the sensations of …
Adeno-associated virus–based gene therapy treats inflammatory kidney disease in mice
G Wu, S Liu, J Hagenstein, M Alawi, FE Hengel… - The Journal of clinical …, 2024 - jci.org
Adeno-associated virus (AAV) is a promising in vivo gene delivery platform showing
advantages in delivering therapeutic molecules to difficult or undruggable cells. However …
advantages in delivering therapeutic molecules to difficult or undruggable cells. However …