Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

Skin architecture and function depend on diverse populations of epidermal cells and dermal
fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in …

Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …

Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical
and biochemical signals in their local microenvironment to regulate genomic programs via …

Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to
proliferate in early postnatal life. Here, we propose a model in which a negative feedback …

Extracellular vesicles (EVs) play an important role in the biology of various organisms,
including fungi, in which they are required for the trafficking of molecules across the cell wall …

Cellular quiescence is a reversible non-proliferating state. The reactivation of 'sleep-
like'quiescent cells (eg fibroblasts, lymphocytes and stem cells) into proliferation is crucial for …

Fibroblasts are the major cell population in the connective tissue of most organs, where they
are essential for their structural integrity. They are best known for their role in remodelling …

The aging of the population in the United States and throughout the developed world has
increased morbidity and mortality attributable to lung disease, while the morbidity and …