Macrophages represent a key cellular component of the liver, and are essential for
maintaining tissue homeostasis and ensuring rapid responses to hepatic injury. Our …

Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood
system after transplantation, which is a curative therapy for numerous diseases including …

Abstract Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of
maintaining a diverse pool of blood cells throughout the human life. Despite recent efforts …

The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology
under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show …

Rare multipotent haematopoietic stem cells (HSCs) in adult bone marrow with extensive self-
renewal potential can efficiently replenish all myeloid and lymphoid blood cells, securing …

Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout
the life of an organism. Knowing the identity of the stem cell is crucial to understanding …

Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis.
In the past decade, the genomics revolution has ushered in powerful new methods for …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Single-cell expression profiling reveals the molecular states of individual cells with
unprecedented detail. Because these methods destroy cells in the process of analysis, they …