[HTML][HTML] The impact of AGEs on human health and the development of their inhibitors based on natural compounds

M Sadeghi, M Miroliaei, A Kamyabiamineh… - Arabian Journal of …, 2023 - Elsevier
Advanced glycation end products (AGEs) are a heterogeneous group of complex chemical
entities resulting from non-enzymatic reactions between reducing sugars with proteins, lipids …

Isofraxidin: Antioxidant, Anti‐carbonic Anhydrase, Anti‐cholinesterase, Anti‐diabetic, and in Silico Properties

L Durmaz, İ Gulçin, P Taslimi, B Tüzün - ChemistrySelect, 2023 - Wiley Online Library
The development of innovative pharmacological formulations for the treatment and
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …

Exploring the inhibitory properties of biflavonoids on α-glucosidase; computational and experimental approaches

M Sadeghi, M Miroliaei, M Ghanadian… - International Journal of …, 2023 - Elsevier
Biflavonoids (BFs) are a group of polyphenols that have a unique biochemical structure. One
of the key biomedical mechanisms that BFs can have high potential in managing Diabetes …

Synthesis, characterization, crystal structure, molecular dynamics simulations, MM-GBSA analysis, and bioactivity studies of pyrazine-and pyrimidine-modulated …

GG Abbasova, RH Ismayilov, DB Tagiyev… - Journal of Molecular …, 2024 - Elsevier
By using unsymmetrical pyrazine-and pyrimidine-modulated oligo-α-pyridylamine ligand N-
(4-methylpyrimidin-2-yl) pyrazin-2-amine (Hmpmpza)(1), 1D copper (II) coordination …

Synthesis, characterization, biochemical, and molecular modeling studies of carvacrol‐based new thiosemicarbazide and 1, 3, 4‐thiadiazole derivatives

T Alagöz, FG Çalişkan, HG Bilgiçli… - Archiv der …, 2023 - Wiley Online Library
A series of carvacrol‐based thiosemicarbazide (3a–e) and 1, 3, 4‐thiadiazole‐2‐amine (4a–
e) were designed and synthesized for the first time. The structures were characterized by …

Phenyldiazenyl-phenoxy-1, 2, 3-triazol-acetamide derivatives as new dual cholinesterase Inhibitors: Design, synthesis, in vitro, and in silico enzymatic inhibition …

S Zareei, M Mohammadi-Khanaposhtani… - Journal of Molecular …, 2025 - Elsevier
In this work, phenyldiazenyl-phenoxy-1, 2, 3-triazol-acetamide as new scaffold was
designed by molecular hybridization of the active pharmacophores in the cholinesterase …

Novel complex compounds of nickel with 3-(1-phenyl-2, 3-dimethyl-pyrazolone-5) azopentadione-2, 4: synthesis, NBO analysis, reactivity descriptors and in silico and …

S Tahirli, F Aliyeva, H Şenol… - Journal of …, 2024 - Taylor & Francis
A synthesized azo compound based on 4-amino antipyrine and its complexes with Ni (II) in
solution and solid phase is reported. The structures of these compounds have been testified …

The synthesis, carbonic anhydrase and acetylcholinesterase inhibition effects of sulfonyl chloride moiety containing oxazolidinones using an intramolecular aza …

A Yıldırım, U Atmaca, E Şahin, P Taslimi… - Journal of …, 2025 - Taylor & Francis
Oxazolidinones are used as various potent antibiotics, in organisms it acts as a protein
synthesis inhibitor, focusing on an initial stage that encompasses the tRNA binding process …

Interactions of novel 1, 3-diaryltriazene-sulfamethazines with carbonic anhydrases: Kinetic studies and in silico simulations

N Lolak, C Türkeş, S Akocak, HE Duran, M Işık… - Archives of Biochemistry …, 2024 - Elsevier
Sulfonamides, recognized as carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors, are crucial in
treating diverse diseases, including epilepsy, glaucoma, bacterial infections, and various …