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[HTML][HTML] The impact of AGEs on human health and the development of their inhibitors based on natural compounds
Advanced glycation end products (AGEs) are a heterogeneous group of complex chemical
entities resulting from non-enzymatic reactions between reducing sugars with proteins, lipids …
entities resulting from non-enzymatic reactions between reducing sugars with proteins, lipids …
Isofraxidin: Antioxidant, Anti‐carbonic Anhydrase, Anti‐cholinesterase, Anti‐diabetic, and in Silico Properties
The development of innovative pharmacological formulations for the treatment and
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …
Exploring the inhibitory properties of biflavonoids on α-glucosidase; computational and experimental approaches
Biflavonoids (BFs) are a group of polyphenols that have a unique biochemical structure. One
of the key biomedical mechanisms that BFs can have high potential in managing Diabetes …
of the key biomedical mechanisms that BFs can have high potential in managing Diabetes …
Screening of Antiglaucoma, Antidiabetic, Anti-Alzheimer, and Antioxidant Activities of Astragalus alopecurus Pall—Analysis of Phenolics Profiles by LC-MS/MS
Astragalus species are traditionally used for diabetes, ulcers, leukemia, wounds,
stomachaches, sore throats, abdominal pain, and toothaches. Although the preventive …
stomachaches, sore throats, abdominal pain, and toothaches. Although the preventive …
Synthesis, characterization, crystal structure, molecular dynamics simulations, MM-GBSA analysis, and bioactivity studies of pyrazine-and pyrimidine-modulated …
By using unsymmetrical pyrazine-and pyrimidine-modulated oligo-α-pyridylamine ligand N-
(4-methylpyrimidin-2-yl) pyrazin-2-amine (Hmpmpza)(1), 1D copper (II) coordination …
(4-methylpyrimidin-2-yl) pyrazin-2-amine (Hmpmpza)(1), 1D copper (II) coordination …
Synthesis, characterization, biochemical, and molecular modeling studies of carvacrol‐based new thiosemicarbazide and 1, 3, 4‐thiadiazole derivatives
A series of carvacrol‐based thiosemicarbazide (3a–e) and 1, 3, 4‐thiadiazole‐2‐amine (4a–
e) were designed and synthesized for the first time. The structures were characterized by …
e) were designed and synthesized for the first time. The structures were characterized by …
Phenyldiazenyl-phenoxy-1, 2, 3-triazol-acetamide derivatives as new dual cholinesterase Inhibitors: Design, synthesis, in vitro, and in silico enzymatic inhibition …
S Zareei, M Mohammadi-Khanaposhtani… - Journal of Molecular …, 2025 - Elsevier
In this work, phenyldiazenyl-phenoxy-1, 2, 3-triazol-acetamide as new scaffold was
designed by molecular hybridization of the active pharmacophores in the cholinesterase …
designed by molecular hybridization of the active pharmacophores in the cholinesterase …
Novel complex compounds of nickel with 3-(1-phenyl-2, 3-dimethyl-pyrazolone-5) azopentadione-2, 4: synthesis, NBO analysis, reactivity descriptors and in silico and …
S Tahirli, F Aliyeva, H Şenol… - Journal of …, 2024 - Taylor & Francis
A synthesized azo compound based on 4-amino antipyrine and its complexes with Ni (II) in
solution and solid phase is reported. The structures of these compounds have been testified …
solution and solid phase is reported. The structures of these compounds have been testified …
The synthesis, carbonic anhydrase and acetylcholinesterase inhibition effects of sulfonyl chloride moiety containing oxazolidinones using an intramolecular aza …
Oxazolidinones are used as various potent antibiotics, in organisms it acts as a protein
synthesis inhibitor, focusing on an initial stage that encompasses the tRNA binding process …
synthesis inhibitor, focusing on an initial stage that encompasses the tRNA binding process …
Interactions of novel 1, 3-diaryltriazene-sulfamethazines with carbonic anhydrases: Kinetic studies and in silico simulations
Sulfonamides, recognized as carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors, are crucial in
treating diverse diseases, including epilepsy, glaucoma, bacterial infections, and various …
treating diverse diseases, including epilepsy, glaucoma, bacterial infections, and various …