Early on, comparisons of known SPs indicated that they typically have three distinct domains
(Fig. 1): an amino-terminal positively charged region (n-region, 1-5 residues long); a central …

The etiology of nerve cell death in neuronal degenerative diseases is unknown, but it has
been hypothesized that excitotoxic mechanisms may play a role. Such mechanisms may …

Mitochondria are important regulators of macrophage polarisation. Here, we show that
arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein …

INTRODUCTION of Ca2+ indicators (photoproteins, fluorescent dyes) that can be trapped in
the cytosolic compartment of living cells has yielded major advances in our knowledge of …

A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into
oligomeric complexes of proteins imported into the mitochondrial matrix. hsp60 is a member …

* Abbreviations used in this paper: BWS, Beckwith-Wiedemann syndrome; HDAC, histone
deacetylase; MIP, mitochondrial intermediate peptidase; MPP, matrix processing peptidase; …

MITOCHONDRIA take up and extrude various inorganic and organic ions, as well as larger
substances such as proteins1–4. The technique of patch clam** should provide real-time …

The Membranes of Cells, Third Edition, provides a basic guide to biomembranes,
connecting researchers to the numerous fields of biology. The new edition offers a complete …

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of
mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of …

Mitochondria are complex organelles with a highly dynamic distribution and internal
organization. Here, we demonstrate that mitofilin, a previously identified mitochondrial …