Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to
involve only the optic nerves and spinal cord. However, the discovery of highly specific anti …

Neuromyelitis optica (NMO, Devic's syndrome), long considered a clinical variant of multiple
sclerosis, is now regarded as a distinct disease entity. Major progress has been made in the …

Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4
(AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been …

Neuromyelitis optica (also known as Devic's disease) is an idiopathic, severe, demyelinating
disease of the central nervous system that preferentially affects the optic nerve and spinal …

Background: The authors previously proposed diagnostic criteria for neuromyelitis optica
(NMO) that facilitate its distinction from prototypic multiple sclerosis (MS). However, some …

Neuromyelitis optica and neuromyelitis optica spectrum disorders have been recently
associated with the disease-specific autoantibody aquaporin-4, thought to be pathogenic …

Summary The term 'neuromyelitis optica'('Devic's syndrome', NMO) refers to a syndrome
characterized by optic neuritis and myelitis. In recent years, the condition has raised …

Background and objectives Diagnosis of multiple sclerosis (MS) requires exclusion of
diseases that could better explain the clinical and paraclinical findings. A systematic process …

Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …

Antibodies to aquaporin‐4 (called NMO‐IgG or AQP4‐Ab) constitute a sensitive and highly
specific serum marker of neuromyelitis optica (NMO) that can facilitate the differential …