Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Background Increased peripheral inflammation has been consistently reported in patients
with major depressive disorder (MDD). However, only few studies have explored markers of …

Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …

Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

Glial fibrillary acidic protein (GFAP), a type III intermediate filament, is a marker of mature
astrocytes. The expression of GFAP gene is regulated by many transcription factors (TFs) …

Postmortem investigations have implicated astrocytes in many neurological and psychiatric
conditions. Multiple brain regions from individuals with major depressive disorder (MDD) …

Background Vascular depression is regarded as a subtype of late-life depression
characterized by a distinct clinical presentation and an association with cerebrovascular …

Major depressive disorder (MDD) is a chronic and recurrent psychiatric condition
characterized by depressed mood, social isolation and anhedonia. It will affect 20% of …

Brain gene expression profiling studies of suicide and depression using oligonucleotide
microarrays have often failed to distinguish these two phenotypes. Moreover, next …