Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials

ZY Ong, N Wiradharma, YY Yang - Advanced drug delivery reviews, 2014 - Elsevier
Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms
have emerged as an exciting class of antimicrobial agents with tremendous potential to …

Peptides as therapeutics with enhanced bioactivity

D Goodwin, P Simerska, I Toth - Current medicinal chemistry, 2012 - ingentaconnect.com
The development of techniques for efficient peptide production renewed interest in peptides
as therapeutics. Numerous modifications for improving stability, transport and affinity profiles …

Unnatural amino acids: Promising implications for the development of new antimicrobial peptides

X Wang, X Yang, Q Wang, D Meng - Critical Reviews in …, 2023 - Taylor & Francis
The increasing incidence and rapid spread of bacterial resistance to conventional antibiotics
are a serious global threat to public health, highlighting the need to develop new …

The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi

AE Kuvarina, IA Gavryushina, AB Kulko, IA Ivanov… - Journal of Fungi, 2021 - mdpi.com
Novel antimicrobial peptides with antifungal and cytotoxic activity were derived from the
alkalophilic fungus Emericellopsis alkalina VKPM F1428. We previously reported that this …

Fungi-derived lipopeptide antibiotics developed since 2000

P Zhao, Y Xue, X Li, J Li, Z Zhao, C Quan, W Gao, X Zu… - Peptides, 2019 - Elsevier
Lipopeptide antibiotics have linear or cyclic structures with one or more hydrocarbon tails
linked to the N-terminus of a short oligopeptide that may be chemically modified and/or …

Haloalkalitolerant Fungi from Sediments of the Big Tambukan Saline Lake (Northern Caucasus): Diversity and Antimicrobial Potential

ML Georgieva, EN Bilanenko, VB Ponizovskaya… - Microorganisms, 2023 - mdpi.com
We have performed a characterization of cultivated haloalkalitolerant fungi from the
sediments of Big Tambukan Lake in order to assess their biodiversity and antimicrobial …

Trichogin GA IV: A versatile template for the synthesis of novel peptaibiotics

M De Zotti, B Biondi, C Peggion, F Formaggio… - Organic & …, 2012 - pubs.rsc.org
Trichogin GA IV, isolated from the fungus Trichoderma longibrachiatum, is the prototype of
lipopeptaibols, the sub-class of short-length peptaibiotics exhibiting membrane-modifying …

The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach

A Dalzini, C Bergamini, B Biondi, M De Zotti… - Scientific reports, 2016 - nature.com
Peptaibols are peculiar peptides produced by fungi as weapons against other
microorganisms. Previous studies showed that peptaibols are promising peptide-based …

Total synthesis of the natural, medium‐length, peptaibol pentadecaibin and study of the chemical features responsible for its membrane activity

L Morbiato, DSA Haneen, F Formaggio… - Journal of Peptide …, 2023 - Wiley Online Library
Peptaibols are naturally occurring, antimicrobial peptides endowed with well‐defined helical
conformations and resistance to proteolysis. Both features stem from the presence in their …

Peptaibols as potential antifungal and anticancer antibiotics: Current and foreseeable development

IA Gavryushina, ML Georgieva, AE Kuvarina… - Applied Biochemistry …, 2021 - Springer
Today's shortage of effective antimicrobial agents can be overcome by using antimicrobial
peptides, which are produced naturally by a wide range of organisms, including …