Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials
Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms
have emerged as an exciting class of antimicrobial agents with tremendous potential to …
have emerged as an exciting class of antimicrobial agents with tremendous potential to …
Peptides as therapeutics with enhanced bioactivity
D Goodwin, P Simerska, I Toth - Current medicinal chemistry, 2012 - ingentaconnect.com
The development of techniques for efficient peptide production renewed interest in peptides
as therapeutics. Numerous modifications for improving stability, transport and affinity profiles …
as therapeutics. Numerous modifications for improving stability, transport and affinity profiles …
Unnatural amino acids: Promising implications for the development of new antimicrobial peptides
X Wang, X Yang, Q Wang, D Meng - Critical Reviews in …, 2023 - Taylor & Francis
The increasing incidence and rapid spread of bacterial resistance to conventional antibiotics
are a serious global threat to public health, highlighting the need to develop new …
are a serious global threat to public health, highlighting the need to develop new …
The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi
AE Kuvarina, IA Gavryushina, AB Kulko, IA Ivanov… - Journal of Fungi, 2021 - mdpi.com
Novel antimicrobial peptides with antifungal and cytotoxic activity were derived from the
alkalophilic fungus Emericellopsis alkalina VKPM F1428. We previously reported that this …
alkalophilic fungus Emericellopsis alkalina VKPM F1428. We previously reported that this …
Fungi-derived lipopeptide antibiotics developed since 2000
P Zhao, Y Xue, X Li, J Li, Z Zhao, C Quan, W Gao, X Zu… - Peptides, 2019 - Elsevier
Lipopeptide antibiotics have linear or cyclic structures with one or more hydrocarbon tails
linked to the N-terminus of a short oligopeptide that may be chemically modified and/or …
linked to the N-terminus of a short oligopeptide that may be chemically modified and/or …
Haloalkalitolerant Fungi from Sediments of the Big Tambukan Saline Lake (Northern Caucasus): Diversity and Antimicrobial Potential
ML Georgieva, EN Bilanenko, VB Ponizovskaya… - Microorganisms, 2023 - mdpi.com
We have performed a characterization of cultivated haloalkalitolerant fungi from the
sediments of Big Tambukan Lake in order to assess their biodiversity and antimicrobial …
sediments of Big Tambukan Lake in order to assess their biodiversity and antimicrobial …
Trichogin GA IV: A versatile template for the synthesis of novel peptaibiotics
M De Zotti, B Biondi, C Peggion, F Formaggio… - Organic & …, 2012 - pubs.rsc.org
Trichogin GA IV, isolated from the fungus Trichoderma longibrachiatum, is the prototype of
lipopeptaibols, the sub-class of short-length peptaibiotics exhibiting membrane-modifying …
lipopeptaibols, the sub-class of short-length peptaibiotics exhibiting membrane-modifying …
The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach
A Dalzini, C Bergamini, B Biondi, M De Zotti… - Scientific reports, 2016 - nature.com
Peptaibols are peculiar peptides produced by fungi as weapons against other
microorganisms. Previous studies showed that peptaibols are promising peptide-based …
microorganisms. Previous studies showed that peptaibols are promising peptide-based …
Total synthesis of the natural, medium‐length, peptaibol pentadecaibin and study of the chemical features responsible for its membrane activity
Peptaibols are naturally occurring, antimicrobial peptides endowed with well‐defined helical
conformations and resistance to proteolysis. Both features stem from the presence in their …
conformations and resistance to proteolysis. Both features stem from the presence in their …
Peptaibols as potential antifungal and anticancer antibiotics: Current and foreseeable development
IA Gavryushina, ML Georgieva, AE Kuvarina… - Applied Biochemistry …, 2021 - Springer
Today's shortage of effective antimicrobial agents can be overcome by using antimicrobial
peptides, which are produced naturally by a wide range of organisms, including …
peptides, which are produced naturally by a wide range of organisms, including …