The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …

Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

Immunity in higher organisms can be broadly categorized into adaptive immunity and innate
immunity. Adaptive immunity is mediated by clonally distributed T and B lymphocytes which …

▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Since the description of the first mouse knockout for an IgG Fc receptor seven years ago,
considerable progress has been made in defining the in vivo functions of these receptors in …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

The transport of Toll-like Receptors (TLRs) to various organelles has emerged as an
essential means by which innate immunity is regulated. While most of our knowledge is …

CONCLUSION The notion that inflammation is the net resultant of pro and contra
inflammatory pathways (Fauve, 1980) is well illustrated by the dual role of neutrophils which …