Pulmonary arterial hypertension: pathogenesis and clinical management

T Thenappan, ML Ormiston, JJ Ryan, SL Archer - Bmj, 2018 - bmj.com
Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …

A global view of pulmonary hypertension

MM Hoeper, M Humbert, R Souza, M Idrees… - The Lancet …, 2016 - thelancet.com
Pulmonary hypertension is a substantial global health issue. All age groups are affected with
rapidly growing importance in elderly people, particularly in countries with ageing …

Molecular genetic framework underlying pulmonary arterial hypertension

L Southgate, RD Machado, S Gräf… - Nature Reviews …, 2020 - nature.com
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder typified by occlusion
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …

Pathology and pathobiology of pulmonary hypertension: current insights and future directions

C Guignabert, J Aman, S Bonnet… - European …, 2024 - publications.ersnet.org
In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …

Global pulmonary vascular remodeling in pulmonary hypertension associated with heart failure and preserved or reduced ejection fraction

AU Fayyaz, WD Edwards, JJ Maleszewski, EA Konik… - Circulation, 2018 - Am Heart Assoc
Background: We hypothesized that pulmonary venous hypertension in heart failure (HF)
leads to predominate remodeling of pulmonary veins and that the severity of venous …

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective

S Halawa, SS Pullamsetti, CRM Bangham… - Nature Reviews …, 2022 - nature.com
The lungs are the primary target of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection, with severe hypoxia being the cause of death in the most critical cases …

Management of pulmonary arterial hypertension

VV McLaughlin, SJ Shah, R Souza… - Journal of the American …, 2015 - jacc.org
Pulmonary hypertension (PH) is common and may result from a number of disorders,
including left heart disease, lung disease, and chronic thromboembolic disease. Pulmonary …

Pulmonary vascular remodeling in pulmonary hypertension

RM Tuder - Cell and tissue research, 2017 - Springer
Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension
and involves changes in the intima, media and adventitia, often with the interplay of …

Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension

T Thenappan, SY Chan… - American Journal of …, 2018 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the extracellular
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …

Endothelial dysfunction in pulmonary hypertension: cause or consequence?

K Kurakula, VFED Smolders, O Tura-Ceide… - Biomedicines, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is
characterized by the abnormal remodeling of the pulmonary arteries that leads to right …