Traditional therapeutic approaches such as chemotherapy and radiation therapy have
burdened cancer patients with onerous physical and psychological challenges …

Receptors enable cells to detect, process and respond to information about their
environments. Over the past two decades, synthetic biologists have repurposed physical …

Generative biology combines artificial intelligence (AI), advanced life sciences technologies,
and automation to revolutionize the process of designing novel biomolecules with …

Synthetic transcription factors (synTFs) that control beneficial transgene expression are an
important method to increase the safety and efficacy of cell and gene therapy. Reliance on …

Interactions between the SARS-CoV-2 Spike protein and ACE2 are one of the most
scrutinized reactions of our time. Yet, questions remain as to the impact of glycans on …

The Chinese hamster ovary (CHO) cell line is a well-established platform for the production
of biopharmaceuticals due to its ability to express complex therapeutic proteins with human …

Enhancers play a critical role in dynamically regulating spatial-temporal gene expression
and establishing cell identity, underscoring the significance of designing them with specific …

For mammalian synthetic biology research, multiple orthogonal and tunable gene
expression systems have been developed, among which the tetracycline (Tet)-inducible …

Bottom-up approaches are becoming increasingly popular for studying multicellular self-
organization and development. In contrast to the classic top-down approach, where parts of …

Gene regulation via chemically induced dimerization (CID) is useful for biomedical research.
However, the number, type, versatility, and in vivo applications of CID tools remain limited …