P-Glycoprotein serves as a gatekeeper in the blood-brain-barrier wherein, it shows a vital
part in the elimination of xenobiotics, drugs, foreign molecules etc. and guards the central …

The aminoglycosides and aminocyclitols are bactericidal antibiotics primarily used to treat
serious infections caused by aerobic gram‐negative bacteria and staphylococci. Amikacin …

Spirocerca lupi is a nematode infecting dogs mostly in tropical and subtropical areas.
Although its typical target is the esophageal wall, aberrant migration is not uncommon …

Spirocerca lupi is a nematode typically targeting the esophageal wall but may also migrate
to the spinal cord. This study aimed to characterize the clinical presentation, cerebrospinal …

Adult heartworm (Dirofilaria immitis or DI) infection in dogs creates both an immediate
problem and an interesting system to study. As an immediate problem, the worm acts as a …

Insecticide resistance has become an increasingly serious challenge for agriculture in the
world. To reveal the mechanisms of insecticide resistance, majority of studies have been …

Introduction: Multidrug resistance (MDR) is primarily associated with reduced intracellular
drug accumulation owing to overexpression of p-glycoprotein, an active efflux transporter …

Background Combination doxycycline/macrocyclic lactone (ML) protocols have been shown
to provide a more rapid adulticidal and microfilaricidal effect than either MLs or doxycycline …

The tetracyclines are the class of antimicrobials with the highest use in veterinary medicine.
The tetracyclines are polyketides with the core structure consisting of a hydronaphthacene …

Due to their marked larvicidal activity, macrocyclic lactones (MLs) are used for the
prevention of heartworm disease (Dirofilaria immitis) in dogs. They have also been shown to …