At least five muscarinic receptors genes have been cloned and expressed. Muscarinic
receptors act via activation of G proteins: m1, m3 and m5 muscarinic receptors couple to …

In multicellular organisms from Caenorhabditis elegans to Homo sapiens, the maintenance
of homeostasis is dependent on the continual flow and processing of information through a …

Using subtype-specific antisera, we were able to identify the recently described alpha
subunits of G12 and G13 in platelet membranes as 43-kDa proteins. Activation of the …

Activating mutations in Gαq proteins, which form the α subunit of certain heterotrimeric G
proteins, drive uveal melanoma oncogenesis by triggering multiple downstream signaling …

Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic
nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory …

Purified Ml muscarlnlc cholinergic receptor and G,, M were coreconstituted in llpid vesicles.
Addition of purifled phospholipase C-p1 (PLC-pl) further stimulated the receptor-promoted …

Background Patients with essential hypertension have abnormal endothelium-dependent
vascular relaxation, largely related to reduced bioactivity of nitric oxide (NO). The purpose of …

The beta gamma subunits (G beta gamma) of heterotrimeric G proteins modulate the activity
of several signal-transducing effector molecules including G protein-coupled receptor …

This review focuses on two phospholipase activities involved in eukaryotic signal
transduction. The action of the phosphatidylinositol-specific phospholipase C enzymes …

THE activation of heterotrimeric G proteins results in the exchange of GDP bound to the α-
subunit for GTP and the subsequent dissociation of a complex of the β-and γ-subunits (Gβγ) …