The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …

Highlights•Discovery of novel post-translational modifications in natural product
biosynthesis.•An enzyme that methylates the backbone amides of ribosomally synthesized …

mRNA display is revolutionizing peptide drug discovery through its ability to quickly identify
potent peptide binders of therapeutic protein targets. Methods to expand the chemical …

It has been well established that the ribosome can accept various nucleophiles on the Xacyl-
tRNA in the A site during elongation, where X can be amino, N-alkyl-amino, hydroxy, and …

In ribosomal translation, the accommodation of aminoacyl-tRNAs into the ribosome is
mediated by elongation factor thermo unstable (EF-Tu). The structures of proteinogenic …

Genetic code expansion is one of the most powerful technologies in protein engineering. In
addition to the 20 canonical amino acids, the expanded genetic code is supplemented by …

The search for new bioactive molecules remains an open challenge limiting our ability to
discover new drugs to treat disease and chemical probes to comprehensively study …

Expanding the chemical repertoire of natural and artificial protein-based polymers (PBPs)
can enable the production of sequence-defined, yet chemically diverse, biopolymers with …

The secreted Chorismate mutase enzyme of Mycobacterium tuberculosis (* Mtb CM) is an
underexplored potential target for the development of new antitubercular agents that are …

Histone deacetylases (HDACs) remove acetyl groups from histone proteins and are
implicated in gene regulation. They have been recognized as drug targets for treatment of …