Microfluidic approaches for cancer cell detection, characterization, and separation

J Chen, J Li, Y Sun - Lab on a Chip, 2012 - pubs.rsc.org
This article reviews the recent developments in microfluidic technologies for in vitro cancer
diagnosis. We summarize the working principles and experimental results of key microfluidic …

Rare cell isolation and analysis in microfluidics

Y Chen, P Li, PH Huang, Y **e, JD Mai, L Wang… - Lab on a Chip, 2014 - pubs.rsc.org
Rare cells are low-abundance cells in a much larger population of background cells.
Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells …

ApoStream™, a new dielectrophoretic device for antibody independent isolation and recovery of viable cancer cells from blood

V Gupta, I Jafferji, M Garza, VO Melnikova… - …, 2012 - pubs.aip.org
Isolation and enumeration of circulating tumor cells (CTCs) are used to monitor metastatic
disease progression and guide cancer therapy. However, currently available technologies …

Isolation of circulating tumor cells by dielectrophoresis

PRC Gascoyne, S Shim - Cancers, 2014 - mdpi.com
Dielectrophoresis (DEP) is an electrokinetic method that allows intrinsic dielectric properties
of suspended cells to be exploited for discrimination and separation. It has emerged as a …

Isolation of rare cells from cell mixtures by dielectrophoresis

PRC Gascoyne, J Noshari, TJ Anderson… - …, 2009 - Wiley Online Library
The application of dielectrophoretic field‐flow fractionation (depFFF) to the isolation of
circulating tumor cells (CTCs) from clinical blood specimens was studied using simulated …

Antibody-independent isolation of circulating tumor cells by continuous-flow dielectrophoresis

S Shim, K Stemke-Hale, AM Tsimberidou, J Noshari… - …, 2013 - pubs.aip.org
Circulating tumor cells (CTCs) are prognostic markers for the recurrence of cancer and may
carry molecular information relevant to cancer diagnosis. Dielectrophoresis (DEP) has been …

Detection and isolation of circulating tumor cells: principles and methods

H Esmaeilsabzali, TV Beischlag, ME Cox… - Biotechnology …, 2013 - Elsevier
Efforts to improve the clinical management of several cancers include finding better methods
for the quantitative and qualitative analysis of circulating tumor cells (CTCs). However …

Correlations between the dielectric properties and exterior morphology of cells revealed by dielectrophoretic field‐flow fractionation

PRC Gascoyne, S Shim, J Noshari, FF Becker… - …, 2013 - Wiley Online Library
Although dielectrophoresis (DEP) has great potential for addressing clinical cell isolation
problems based on cell dielectric differences, a biological basis for predicting the DEP …

Interdigitated comb‐like electrodes for continuous separation of malignant cells from blood using dielectrophoresis

A Alazzam, I Stiharu, R Bhat… - Electrophoresis, 2011 - Wiley Online Library
In this paper, a method for continuous flow separation of circulating malignant cells from
blood in a microfluidic device using dielectrophoresis is discussed. Separation of MDA231 …

Dielectrophoretic manipulation of cancer cells and their electrical characterization

I Turcan, MA Olariu - ACS Combinatorial Science, 2020 - ACS Publications
Electromanipulation and electrical characterization of cancerous cells is becoming a topic of
high interest as the results reported to date demonstrate a good differentiation among …