The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …

Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …

Importance Physical health and chronic medical comorbidities are underestimated,
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …

Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …

Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …