Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Restorative strategies after stroke are focused on the remodeling of cerebral endothelial
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …

Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models
by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has …

In recent years, stem cell‐based approaches have attracted more attention from scientists
and clinicians due to their possible therapeutical effect on stroke. Animal studies have …

Abstract Coronavirus disease 19 (COVID-19) is a respiratory illness caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes …

Cell therapies are increasingly recognized as a promising option to augment the limited
therapeutic arsenal available to fight ischemic stroke. During the last two decades …

Heat shock proteins (Hsps) are induced by heat shock via heat shock factor proteins binding
to heat shock elements in their promoters. Hsp70 is massively induced in response to …

Stroke is the number one cause of morbidity in the United States and number two cause of
death worldwide. There is a critical unmet medical need for more effective treatments of …