Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

Gliomas are the most prevalent primary malignant brain tumors worldwide, with
glioblastoma (GBM) being the most common and aggressive type. Despite two decades of …

A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …

Immune checkpoint inhibitors have been successful across several tumor types; however,
their efficacy has been uncommon and unpredictable in glioblastomas (GBM), where< 10 …

Background Immunosuppressive microenvironment is a major cause of immunotherapeutic
resistance in glioma. In addition to secreting compounds, tumor cells under programmed cell …

Cell detection is a fundamental task in computational pathology that can be used for
extracting high-level medical information from whole-slide images. For accurate cell …

Glioblastoma (GBM), the most common malignant primary brain cancer in adults, nearly
always becomes resistant to current treatments, including the chemotherapeutic …

N6-methyladenosine (m6A) RNA methylation, associated with cancer initiation and
progression, is dynamically regulated by the m6A RNA methylation regulators …

Glioblastoma (GBM) is a lethal form of primary brain tumor in human adults. The impact of
tumor-intrinsic alterations is not exclusively confined to cancer cells but can also be …

ACT001, which is derived from an ancient anti-inflammatory drug, has been shown to cross
the blood-brain barrier in preclinical studies and has demonstrated anti-glioblastoma (GBM) …