Research on the discovery and characterization of small, regulatory RNAs in bacteria has
exploded in recent years. These sRNAs act by base pairing with target mRNAs with which …

Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key
roles in the control of gene expression. By facilitating the pairing of small RNAs with their …

Small regulatory RNA (sRNAs) are key mediators of posttranscriptional gene control in
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …

Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal
cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

The continuous degradation and synthesis of prokaryotic mRNAs not only give rise to the
metabolic changes that are required as cells grow and divide but also rapid adaptation to …

Small non-coding RNAs (sRNAs) are an emerging class of regulators of bacterial gene
expression. Most of the regulatory Escherichia coli sRNAs known to date modulate …

Recent studies on Hfq have provided a deeper understanding of the multiple functions of
this pleiotropic post-transcriptional regulator. Insights into the mechanism of Hfq action have …

Bacterial small noncoding RNAs (sRNAs) generally recognize target mRNAs in the 5′
region to prevent 30S ribosomes from initiating translation. It was thought that the mRNA …