Pre-eclampsia

E Dimitriadis, DL Rolnik, W Zhou… - Nature reviews Disease …, 2023 - nature.com
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis

A Conde-Agudelo, R Romero - American journal of obstetrics and …, 2022 - Elsevier
Objective To examine the relationship between SARS-CoV-2 infection during pregnancy
and the risk for preeclampsia. Data Sources MEDLINE, Embase, POPLINE, CINAHL …

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

P Li, H Wang, L Guo, X Gou, G Chen, D Lin, D Fan… - BMC medicine, 2022 - Springer
Background Several recent observational studies have reported that gut microbiota
composition is associated with preeclampsia. However, the causal effect of gut microbiota …

Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy

KL Swingle, HC Safford, HC Geisler… - Journal of the …, 2023 - ACS Publications
Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nonviral platform for
mRNA delivery. While they have been explored for applications including vaccines and …

Clinical tools and biomarkers to predict preeclampsia

TM MacDonald, SP Walker, NJ Hannan, S Tong… - …, 2022 - thelancet.com
Preeclampsia is pregnancy-specific, and significantly contributes to maternal, and perinatal
morbidity and mortality worldwide. An effective predictive test for preeclampsia would …

Local immune recognition of trophoblast in early human pregnancy: controversies and questions

A Moffett, N Shreeve - Nature Reviews Immunology, 2023 - nature.com
The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

Gestational diabetes mellitus and preeclampsia: correlation and influencing factors

Y Yang, N Wu - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy
complications with similar risk factors and pathophysiological changes. Evidence from …

Causality of genetically determined metabolites on anxiety disorders: a two-sample Mendelian randomization study

G **ao, Q He, L Liu, T Zhang, M Zhou, X Li… - Journal of translational …, 2022 - Springer
Background Although anxiety disorders are one of the most prevalent mental disorders, their
underlying biological mechanisms have not yet been fully elucidated. In recent years …

Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia

S Jash, S Banerjee, S Cheng, B Wang, C Qiu… - Nature …, 2023 - nature.com
Preeclampsia (PE) is the leading cause of maternal and fetal mortality globally and may
trigger dementia later in life in mothers and their offspring. However, the etiological drivers …

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

KL Swingle, AG Hamilton, HC Safford, HC Geisler… - Nature, 2025 - nature.com
Pre-eclampsia is a placental disorder that affects 3–5% of all pregnancies and is a leading
cause of maternal and fetal morbidity worldwide 1, 2. With no drug available to slow disease …