Gene expression is a fundamentally stochastic process, with randomness in transcription
and translation leading to cell-to-cell variations in mRNA and protein levels. This variation …

Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …

The complex, interconnected architecture of cell-signaling networks makes it challenging to
disentangle how cells process extracellular information to make decisions. We have …

Gene expression occurs either as an episodic process, characterized by pulsatile bursts, or
as a constitutive process, characterized by a Poisson-like accumulation of gene products. It …

Biological circuits can be controlled by two general schemes: environmental sensing or
autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent …

The molecular mechanisms utilized by human immunodeficiency virus (HIV) to enter latency
are poorly understood. Following the infection of Jurkat T cells with lentiviral vectors that …

Transcriptional positive-feedback loops are widely associated with bistability, characterized
by two stable expression states that allow cells to respond to analog signals in a digital …

Abstract Analysis of noise in gene expression has proven a powerful approach for analyzing
gene regulatory architecture. To probe the regulatory mechanisms controlling expression of …

The therapeutic potential of pharmacologic inhibition of bromodomain and extraterminal
(BET) proteins has recently emerged in hematological malignancies and chronic …

The establishment of HIV proviral latency requires the creation of repressive chromatin
structures that impair the initiation of transcription and restrict RNAP II elongation. We have …