The rise of antimicrobial resistance (AR) is a major threat to global health. The food animal
industry contributes to the increasing occurrence of AR. Multiple factors can affect the …

Molecular de-extinction could offer avenues for drug discovery by reintroducing bioactive
molecules that are no longer encoded by extant organisms. To prospect for antimicrobial …

Big defensins, ancestors of β-defensins, are composed of a β-defensin-like C-terminal
domain and a globular hydrophobic ancestral N-terminal domain. This unique structure is …

Given the current and future costs of antibiotic-resistant bacteria to human health and
economic productivity, there is an urgent need to develop new antimicrobial compounds …

Bacterial antibiotic resistance modulation by small signaling molecules is an emerging
mechanism that has been increasingly reported in recent years. Several studies indicate that …

Multitargeting antibiotics, ie, single compounds capable of inhibiting two or more bacterial
targets, are generally considered to be a promising therapeutic strategy against resistance …

The robust innate immune system of the earthworm provides a potential source of natural
antimicrobial peptides (AMPs). However, the cost and high rediscovery rate of direct …

Listeria monocytogenes is a well-known foodborne pathogen that usually lives as biofilm to
cope with unfavorable surroundings. Bacteriocins have been reported as antimicrobial …

The rise of antibiotic resistant bacteria, such as methicillin-resistant Staphylococcus aureus
(MRSA), requires novel approaches to combat infections. Medical devices like implants and …

Tomatoes are readily available and affordable vegetables that offer a range of health
benefits due to their bioactive molecules, such as antioxidants and antimicrobials. In contrast …