Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Apoptosis, a genetically programmed cellular event leads to biochemical and morphological
changes in cells. Alterations in DNA caused by several factors affect nucleus and ultimately …

A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a
pharmaceutically interesting diverse kind of functionalized 2-amino-3-cyano-4 H-pyrans and …

A cell undergoing apoptosis demonstrates multitude of characteristic morphological and
biochemical features, which vary depending on the inducer of apoptosis, cell type and the …

Defects in the apoptosis mechanism stimulate cancer cell growth and survival. B cell
lymphoma 2 (Bcl-2) is an anti-apoptotic molecule that plays a central role in apoptosis. Bcl-2 …

Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …

Abstract 4H-Pyrans and 4H-pyran-annulated heterocyclic scaffolds represent a “privileged”
structural motif well-distributed in biologically active natural products and also in promising …

In this study, we investigated the mechanism of apoptosis induction of obatoclax (GX15-
070), a novel Bcl-2 homology domain-3 (BH3) mimetic, in acute myeloid leukemia (AML) cell …

Background: Abdominal aortic aneurysm (AAA) is a severe aortic disease with a high
mortality rate in the event of rupture. Pharmacological therapy is needed to inhibit AAA …

A new type of Lewis base-surfactant-combined catalyst (LBSC), sodium stearate, was
applied as a catalyst in three-component one-pot reaction involving isatin, malononitrile, and …