Next generation antibody drugs: pursuit of the'high-hanging fruit'
PJ Carter, GA Lazar - Nature Reviews Drug Discovery, 2018 - nature.com
Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
[HTML][HTML] Intravitreal hydrogels for sustained release of therapeutic proteins
This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …
the posterior segment of the eye in order to increase therapeutic outcome and patient …
Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update
Ocular drug delivery is one of the most challenging endeavors among the various available
drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic …
drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic …
Special features of polyester-based materials for medical applications
This article presents current possibilities of using polyester-based materials in hard and soft
tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery …
tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery …
Atorvastatin-loaded solid lipid nanoparticles as eye drops: proposed treatment option for age-related macular degeneration (AMD)
Statins, widely prescribed for cardiovascular diseases, are also being eyed for management
of age-related macular degeneration (AMD). Poor bioavailability and blood-aqueous barrier …
of age-related macular degeneration (AMD). Poor bioavailability and blood-aqueous barrier …
Polymeric implants for the treatment of intraocular eye diseases: trends in biodegradable and non-biodegradable materials
P García-Estrada, MA García-Bon, EJ López-Naranjo… - Pharmaceutics, 2021 - mdpi.com
Intraocular/Intravitreal implants constitute a relatively new method to treat eye diseases
successfully due to the possibility of releasing drugs in a controlled and prolonged way. This …
successfully due to the possibility of releasing drugs in a controlled and prolonged way. This …
Applications of stimuli-responsive nanoscale drug delivery systems in translational research
Highlights•Nanomedicine is a promising strategy for target-specific delivery of
therapeutics.•Stimuli-responsive nanocarriers enhance tissue specificity.•Advances in …
therapeutics.•Stimuli-responsive nanocarriers enhance tissue specificity.•Advances in …
[HTML][HTML] Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration
Several chronic eye diseases affect the posterior segment of the eye. Among them age-
related macular degeneration can cause vision loss if left untreated and is one of the leading …
related macular degeneration can cause vision loss if left untreated and is one of the leading …
Emerging trends in nanomedicine for improving ocular drug delivery: light-responsive nanoparticles, mesoporous silica nanoparticles, and contact lenses
Vision is the most dominant of our senses, and it is crucial in every stage of our lives. Ocular
diseases, regardless of whether they cause vision impairment or not, lead to personal and …
diseases, regardless of whether they cause vision impairment or not, lead to personal and …
A long-acting curcumin nanoparticle/in situ hydrogel composite for the treatment of uveal melanoma
Uveal melanoma (UM) is the most common primary intraocular tumor in adults with high
mortality. In order to improve prognosis and survival of UM patients, it is critical to inhibit …
mortality. In order to improve prognosis and survival of UM patients, it is critical to inhibit …