Both safety and efficacy of medical treatment can vary depending on the ethnogeographic
background of the patient. One of the reasons underlying this variability is differences in …

Introduction Thiopurine toxicity is related to genetic polymorphism. Thiopurine
methyltransferase (TPMT) variants do not explain thiopurine toxicity in more than half of …

Background Recent studies reported that Nudix Hydrolase 15 (NUDT 15) gene variant
(C415T) can better predict thiopurine induced leucopenia in Asian patients with …

Background: Prevalence and impact of thiopurine S-methyltransferase (TPMT) and Nudix
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …

Abstract Background and Aim Thiopurines are widely used to maintain remission in both
ulcerative colitis (UC) and Crohn's disease (CD). Reported effectiveness and tolerability …

We herein conducted a systematic review and meta-analysis of published studies to
estimate diagnostic accuracy of NUDT15 gene polymorphisms for detection of thiopurine …

Purpose Infliximab (IFX) therapy in inflammatory bowel disease (IBD) is associated with loss
of response in half the patients, due to complex pharmacokinetic and immunological factors …

Background: Nudix Hydrolase 15 gene (NUDT15) encodes nucleotide triphosphate
diphosphatase which metabolizes the purine analog drugs, such as anticancer thiopurine …

Objective: This study aimed to correlate the genetic profile of the NUDT15 and TPMT genes
with the side effects of the treatment of pediatric patients with acute lymphoid leukemia who …

DEAR EDITOR, Azathioprine is a commonly used immune suppressive agent in various
rheumatic diseases. It is a purine analogue that is metabolized in the liver to 6 …